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Structural genomics on membrane proteins: the MePNet approach.

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Structural Genomics on Membrane Proteins

The network included centers for high-throughput structure determination, centers for membrane protein structure determination, consortia for high-throughput-enabled structural biology partnerships, the SBKB and the PSI-MR. While most of the structures solved by the four large-scale PSI centers lack functional annotation, many of the remaining PSI centers determine structures for proteins with known biological function.


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The TB Structural Genomics Consortium, for example, focused exclusively on functionally characterized proteins. The PSI consortia have provided the overwhelming majority of targets for the Critical Assessment of Techniques for Protein Structure Prediction CASP , a community-wide, biannual experiment to determine the state and progress of protein structure prediction.

A major goal during the PSI:Biology phase is to utilize the high-throughput methods developed during the initiative's first decade to generate protein structures for functional studies, broadening the PSI's biomedical impact. It is also expected to advance knowledge and understanding of membrane proteins. The PSI has received notable criticism from the structural biology community.

These hypothesis-driven proposals are the lifeblood of the scientific enterprise, and as I have discussed recently in other columns, they are being sucked dry by, among other things, an increasing trend to fund large initiatives at their expense. A short response to this was published: [20]. In conclusion, it should be kept in mind that scientific research, and the cutting- edge technologies that both drive and are driven by it, are constantly and rapidly evolving. Representatives of other genomics, proteomics, and structural genomics initiatives, as well as scientists from academia, government, and industry were also included.

Based on this meeting and the subsequent recommendations from the PSI Advisory Committee, [22] [23] a concept-clearance document was released in January describing what a third phase of the PSI might entail.

Cell membrane proteins - Cells - MCAT - Khan Academy

Most notable was a large emphasis on partnerships and collaborations to ensure that the majority of PSI research is focused on proteins of interest to the broader research community as well as efforts to make PSI products more accessible to the research community. See Phase 3 section above.

From Wikipedia, the free encyclopedia. Retrieved December 5, Protein Structure Initiative. Archived from the original on October 1, Retrieved October 12, Archived from the original on June 27, Nature Methods.


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